Thrombogenesis, angiogenesis, and endothelial function in hypertension
نویسندگان
چکیده
منابع مشابه
CARDIOVASCULAR MEDICINE Angiogenesis, thrombogenesis, endothelial dysfunction and angiographic severity of coronary artery disease
Background: Thrombogenesis, angiogenesis, and endothelial damage/dysfunction are components in the pathogenesis of atherosclerosis. Objective: To investigate the relation of these variables to atherosclerotic disease severity and the possible interrelations between the three. Methods: 111 patients attending for coronary angiography were studied (85 male, 26 female; mean (SD) age, 61.6 (10.0) ye...
متن کاملExercise training restores the endothelial progenitor cells number and function in hypertension: implications for angiogenesis.
OBJECTIVES Aerobic exercise training has been established as an important nonpharmacological treatment for hypertension. We investigated whether the number and function of endothelial progenitor cells (EPCs) are restored after exercise training, potentially contributing to neovascularization in hypertension. METHODS Twelve-week-old male spontaneously hypertensive rats (SHRs, n = 14) and Wis...
متن کاملEndothelial function in clinical pulmonary hypertension.
The endothelium regulates the concentrations of several types of vasoactive substances that affect pulmonary vascular tone, and endothelia can oppose vasoconstriction in some circumstances by releasing vasodilators. To assess some of these endothelial functions in patients with pulmonary hypertension, we made measurements of selected vasoactive substances before and during attempts at pharmacol...
متن کاملTorcetrapib impairs endothelial function in hypertension.
AIMS A marked increase in HDL notwithstanding, the cholesterol ester transfer protein (CETP) inhibitor torcetrapib was associated with an increase in all-cause mortality in the ILLUMINATE trial. As underlying mechanisms remain elusive, the present study was designed to delineate potential off-target effects of torcetrapib. METHODS AND RESULTS Spontaneously hypertensive rats (SHRs) and Wistar-...
متن کاملMarkers of Thrombogenesis and Fibrinolysis and Their Relation to Inflammation and Endothelial Activation in Patients with Idiopathic Pulmonary Arterial Hypertension
BACKGROUND Chronic anticoagulation is a standard of care in idiopathic pulmonary arterial hypertension (IPAH). However, hemostatic abnormalities in this disease remain poorly understood. Therefore, we aimed to study markers of thrombogenesis and fibrinolysis in patients with IPAH. METHODS We studied 27 consecutive patients (67% female) with IPAH aged 50.0 years (IQR: 41.0-65.0) and 16 control...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 2002
ISSN: 0735-1097
DOI: 10.1016/s0735-1097(02)80960-3